Abstract Twenty Two



Ann Rheum Dis 1990 May;49(5):283-5

Comparison of long term evolution of adult onset and juvenile onset Still's disease, both followed up for more than 10 years.

Cabane J, Michon A, Ziza JM, Bourgeois P, Bletry O, Godeau P, Kahn MF

Department of Internal Medicine, Pitie-Salpetriere Hospital, Paris,

Still's disease is a clinical entity of unknown origin, which can appear before 15 years of age (juvenile onset Still's disease) or later (adult onset Still's disease). There are few reported data about the long term
prognosis of Still's disease and no study compares the long term evolution of adult onset and juvenile onset Still's disease.

 Eighteen patients fulfilling the American Rheumatism Association criteria for
Still's disease were followed up for more than 10 years. Ten (group 1) had juvenile onset Still's disease and eight (group 2) adult onset
Still's disease. A comparison of the groups showed no significant differences in the initial systemic manifestations of Still's disease,
or in the joint lesions. 

Both groups had severe sequelae, which appeared between six and 10 years after the initial flare up of Still's disease.
Nine patients had articular damage and nine had only arthritis without apparent x ray abnormalities. Nine patients had bilateral hip
destruction in less than four years. Of these nine, seven required 13 total hip replacements before the age of 45. In the whole group of 18
patients bilateral involvement of the following joints was also seen: carpus (seven patients), knee (four), tarsus (four), ankle (three);
three patients had ankylosis of the cervical spine. The occurrence of amyloidosis (three cases, two deaths) was restricted to group 2. 

This was the only difference between the groups, as the treatments were identical. It is concluded that the articular prognosis of Still's
disease is poor, be it adult onset or juvenile onset, with severe joint destruction in half of the patients.

PMID: 2344206, UI: 90262276

Back ] Up ] Next ]


The materials and information on this server are intended for educational and informational purposes only. The materials and information are not intended to replace the services of a trained health professional or to be a substitute for medical advice of physicians and/or other health care professionals. The International Still's Disease Foundation is not engaged in rendering medical or professional medical services. You should consult your physician on specific medical questions, particularly in matters requiring diagnosis or medical attention. The International Still's Disease Foundation makes no representations or warranties with respect to any treatment, action, application medication or preparation by any person following the information offered or provided within this website.  Any information used from other websites was done so with permission from each site, with an exception to those of "public domain", whereas we believe any site without a cited reference was a "public domain site" and for our use.  The International Still's Disease Foundation is a non-profit organization.   This page was last updated on January 17, 2001

Copyrightę 1999-2001 International Still's Disease Foundation