Abstract Thirteen

 

Treatment of Still disease in adults with intravenous
 immunoglobulins

Permal S  Wechsler B  Cabane J  
 Perrot S  Blum L  Imbert JC  

Traitement de la maladie de Still de l'adulte par immunoglobulines
 intraveineuses.

In: Rev Med Interne (1995) 16(4):250-4

ISSN: 0248-8663  (Published in French)

In most cases, the treatment of adult's Still disease presents  difficulties, in view of its undesirable side-effects. For this  reason, we made an open trial of the effects of high-dose intravenous  immunoglobulins (IVIg), a therapy with low iatrogen risk, and whose effectiveness in the treatment of other multisystemic diseases has  been acknowledged. 

Seven patients suffering from adult Still's disease were given between one and eight IVIg infusions with a dose  of 1 g/kg/day for two consecutive days. All seven responded positively, with clinical improvement. It lasted between 1 and 90 days in three patients, who subsequently relapsed; it has been  continuing for an average of 13 months (2 to 24 months) in the other  four patients. There were no clinical features making it possible to  distinguish, after the trial, the patients who responded positively  to intravenous immunoglobulins. 

This data, which needs to be  confirmed with a controlled trial, provides hope of improved therapy  for the one half of patients suffering from adult Still's disease who  respond positively to intravenous immunoglobulins.

Registry Numbers: 9007-73-2 (Ferritin)

Institutional address:
       Service de medecine interne
       hopital Saint-Antoine
       Paris
       France.

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