ELEVATED SERUM LEVELS OF BOTH TH1 AND TH2 CYTOKINES IN PATIENTS WITH ADULT STILL'S DISEASE
J K Min, M L Cho, S
Y Min, S J Kim, W U Kim, Y I Seo, Y S Hong, S H Lee, S H Park, C S Cho, H Y
Kim. Seoul, Republic of Korea.
Methods: We measured serum
levels of Th1 cytokines (interleukin-2, interleukin-12, and interferon-g) and
Th2 cytokines (interleukin-4, interleukin-10, interleukin-13) in patients with
ASD (n=10) and healthy controls (n=50) by sandwich ELISA. The clinical and
laboratory data were obtained when the serum samples were drawn.
Results: Systemic disease was considered active if ASD patients had more than 2 of the followings: fever39░C, rash, lymphadenopathy and/or splenomegaly, sore throat, serositis and/or interstitial pneumonitis, CRP4 mg/dl and/or ESR40 mm/hour, liver dysfunction, and ferritin1,000 ng/ml.
* p<0.05 compared with
Conclusion: Both Th1 and Th2 cytokines are significantly increased in patients with adult Still's disease and may contribute to the disease process.
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