Self-Limited Autoimmune Syndrome Rare in Infliximab-Treated Patients ---------------------------------------------------------------------------- ----

 WESTPORT, CT (Reuters Health) Dec 15, 2000 - The anti-tumor necrosis factor monoclonal antibody infliximab, used to treat rheumatoid arthritis, can induce antibodies to double-stranded DNA, but the risk of developing a reversible lupus syndrome is small, according to a report published in the November issue of Arthritis and Rheumatism. 

Dr. R. N. Maini, from The Kennedy Institute of Rheumatology, in London, and colleagues compared the incidence of anti-double stranded DNA (anti-dsDNA) antibodies occurring in 156 rheumatoid arthritis (RA) patients treated with infliximab and 37 patients treated with placebo. In a previous open-label study, the investigators reported that 2 of 20 patients treated with infliximab developed anti-dsDNA antibodies. "In the subsequent trials that are included in this report, we have observed this phenomenon in a further 20 patients," the authors note. 

However, "only one of these patients showed clinical symptoms suggestive of a drug-induced lupus syndrome." The condition resolved within 8 weeks with oral prednisolone therapy. This patient developed anti-dsDNA IgG, IgM, and IgA antibodies, the researchers report. All other patients who developed anti-dsDNA antibodies manifested only IgM class antibodies. "The lack of clinical disease in all but one patient is notable and may be related to the isotype of the anti-dsDNA produced, since it has been suggested that only IgG class anti-dsDNA antibodies are pathogenic," the authors point out. 

"Data emerging from a larger study of 428 patients suggest that the frequency of induced anti-dsDNA antibodies is similar to the frequency we report here and that the frequency of infliximab-induced lupus is even less, since only 1 other such RA patient has been reported," the investigators note. "Given the benefit of infliximab therapy in the treatment of methotrexate-resistant RA," 

Dr. Maini's group concludes that "the risk of a self-limiting autoimmune syndrome appears to be small and not a significant limitation to its use in clinical practice." Arthritis Rheum 2000;43:2383-2390.

Back ] Up ] Next ]


The materials and information on this server are intended for educational and informational purposes only. The materials and information are not intended to replace the services of a trained health professional or to be a substitute for medical advice of physicians and/or other health care professionals. The International Still's Disease Foundation is not engaged in rendering medical or professional medical services. You should consult your physician on specific medical questions, particularly in matters requiring diagnosis or medical attention. The International Still's Disease Foundation makes no representations or warranties with respect to any treatment, action, application medication or preparation by any person following the information offered or provided within this website.  Any information used from other websites was done so with permission from each site, with an exception to those of "public domain", whereas we believe any site without a cited reference was a "public domain site" and for our use.  The International Still's Disease Foundation is a non-profit organization.   This page was last updated on January 17, 2001

Copyrightę 1999-2001 International Still's Disease Foundation